Immunoglobulin formation in B lymphoid cells.

Immunoglobulin formation in B lymphoid cells.

A considerable amount is known about Ig biosynthesis by mature plasma cells, which form large amounts of Ig for secretion from the cell. A brief summary is given of the formation of light (L) and heavy (H) chains by polyribosomes aligned on the endoplasmic reticulum and the rapid assembly of the chains into 7S molecules (H2L2) by disulphide bonding. There is a time-ordered secretion from the ce...

Immunoglobulin synthesis by salivary gland lymphoid cells in Sjögren's syndrome.

The synthesis of immunoglobulins by cells infiltrating the labial salivary glands has been studied by radioimmunoelectrophoresis in 20 patients with Sjögren's syndrome (SS) and in 14 control patients with related disorders. The patients with SS were producing significantly greater quantities of IgG, IgM, and IgA. Synthesis of IgG and IgM correlated with the degree of lymphoid infiltration but n...

Response to prednisolone of cultured immunoglobulin-producing human lymphoid cells.

The survival of asynchronously growing lymphoid cells (T, cells) in vitro decreased to 50% viability after 1 hr treatment with concentrations of prednisolone above 10 ftg/ml. Treatment with prednisolone for 24 hr produced a decrease in cell survival to a plateau of 30% viability for concentrations above 10 ig/ml. After 48 hr treatment, 10 ig/ml prednisolone reduced viability to 12%. Synchronous...

Avian lymphoid leukosis: Virus-like particles in kidney Cells

Factor B Binding to Lymphoid Cells

A receptor for fluid phase human complement (C) components C3 and C3b (1, 2) was found on the surface membranes of human lymphoblastoid cells. No other C proteins or serum factors were needed to mediate binding of C3 or C3b to this receptor. In studying its biological importance, we demonstrated that Raji cells cultured in medium containing fresh normal human serum (NHS) 1 and cobra venom facto...